Skip to content
Biosciences east and central Africa (BecA) Hub
  • Increase font size
  • Default font size
  • Decrease font size
You are here: Home arrow BecA Hub in action arrow The hub arrow Service units arrow Bioinformatics / LIMS
Bioinformatics / LIMS unit PDF Print E-mail

Group Leader:
Etienne deVilliers, email: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

System Administrator:



The BecA Hub Bioinformatics Platform provides advanced computational capabilities in bioinformatics to all  BecA Hub scientists to:
  • Uncover the wealth of biological information hidden in the mass of DNA sequences, structure, literature and other biological data,
  • Obtain a clearer insight into the fundamental biology of organisms,
  • Use this information to enhance the standard of life for mankind.

The initial focus of the platform is to be an easy-to-use platform for advanced sequence analysis. We make available high-speed, specialized hardware and sophisticated commercial and academic software. To make these useful, we maintain the latest copies of all major sequence databases. Investigators can use these components to perform one-time projects or to build up their own ongoing analysis pipeline.

Bioinformatics unit services:
We provide scientific and technical staff that can assist with or collaborate on individual projects.

As part of the Bioinformatics Platform, we also have access to the advice and expertise of associated BecA staff members. The Bioinformatics Platform is a specialist node of The European Molecular Biology Network (EMBnet) (http://www.embnet.org). EMBnet is a consortium of collaborating bioinformatics groups located in Europe and a number of groups outside Europe.

Each group is represented by a ‘node’, and is responsible for the maintenance of local services for their users (e.g. education, training, software, database distribution, technical support, helpdesk).

The combined expertise of the nodes allows EMBnet to provide services to the bioinformatics community that encompass more than can be provided by a single node.

Bioinformatics unit hardware:
The  BecA Hub Bioinformatics Platform is hosted on a High Performance Computer (HPC) platform located on the BecA, Nairobi campus.

Image

The HPC platform is a 66 CPU Linux cluster, based on AMD 64-bit Opteron technology and build with ROCKS version 4.1. Each compute node contains two 64-bit Opteron processors with 2 GB of memory. Nodes are interconnected with high-speed 1 Gbits/sec networking. In total, the system has 72 GB of memory and more than 3 TB of disk space. Platform LSF scheduling software manages job scheduling.

Paracel BlastMachine runs parallelized versions of NCBI BLAST, PSI-BLAST, and MegaBLAST. It utilizes 20 of the 66 CPUs on the HPC. The BlastMachine accelerates the BLAST algorithms by dividing a job across multiple processors and can divide both the database and the query among groups of processors.

Paracel GeneMatcher2 - accelerates dynamic programming algorithms such as Smith-Waterman, HMMer and Genewise.

Several other Unix file-, web- and data servers are available.

Some things you can do using the bioinformatics platform:
  • Quickly run very large BLAST jobs on our 20-CPU BlastMachine cluster.
  • Search for protein domains or new genes using HMMs and Genewise on the GeneMatcher2.
  • Identify remote homologs - run highly sensitive sequence searches using the Smith-Waterman algorithms on the GeneMatcher2 or using PSI-BLAST accelerated on the BlastMachine.
  • Develop and run parallel MPI jobs on the 66 CPU Linux cluster, or use it as a compute farm for serial jobs.
  • Sophisticated, commercial-quality sequence and EST assembly.
  • We maintain the latest copies of all major sequence databases for each of our platforms - you can set up your own pipeline to run a set of queries at regular intervals against the latest data.
  • Choose from our growing list of academic software packages supported on our machines, including packages for genetic analysis and structural biology.
  • Web-based and UNIX login access to the various machines. We can host large-scale projects. We are working on technologies to allow remote use of our machines.
Image

Capacity building:
Bioinformatics is a relatively new specialist area. We need to raise awareness of the field here in Africa and expose local scientists to its potential. The West has spent millions of dollars sequencing the genomes of humans, animals, plants and parasites and the resulting data are freely available on the Internet. This is a vast body of knowledge that local scientists can use to solve their specific problems or to answer research questions. All scientists in Africa need to make use of these data are a computer, good Internet access and bioinformatics skills.
Image

Raising awareness and building capacity in Bioinformatics in Africa is a major focus of the Bioinformatics Platform. This is accomplished through regular training courses and research projects undertaken at the BecA platform. In association with the Swedish University of Agricultural Sciences and the Linnaeus Centre for Bioinformatics, in Uppsala, Sweden, BecA runs an annual two-week “Introduction to Bioinformatics” training course. Since 2005, we have trained more than 100 students from more than five eastern and central Africa countries in the field of bioinformatics.

Download the Bioinformatic unit brochure Bioinformatics unit brochure Bioinformatics unit brochure 302.28 Kb


Add this page to your favorite Social Bookmarking websites:
Reddit! Del.icio.us! Google! Live! Facebook! StumbleUpon! Yahoo!
 

Gallery


Beca Hub Photos


Add this page to your favorite Social Bookmarking websites:
Reddit! Del.icio.us! Google! Live! Facebook! StumbleUpon! Yahoo!
Site last modified:
Thu, 22 July 2010,
04:38:50 AM

BecA Clippings


View the latest news, articles and features on BecA 
NEW!!



Add this page to your favorite Social Bookmarking websites:
Reddit! Del.icio.us! Google! Live! Facebook! StumbleUpon! Yahoo!

Needs assessment

We want to assess your needs!
 

How to use the Hub

Using the BecA Hub: access protocols
 

Work with us

Explore exciting job opportunities!
 

BecA-ILRI Facilities Upgrade Project


BecA-ILRI Facilities Upgrade Project


Add this page to your favorite Social Bookmarking websites:
Reddit! Del.icio.us! Google! Live! Facebook! StumbleUpon! Yahoo!
 

Searchable Database of Scientists



The BecA internet searchable database of scientists
Please click here


Add this page to your favorite Social Bookmarking websites:
Reddit! Del.icio.us! Google! Live! Facebook! StumbleUpon! Yahoo!