As head of the virology laboratory at the Central Veterinary Laboratories in the Directorate of Veterinary Services (DVS) in Kenya, my responsibilities include laboratory surveillance, and confi rmation and reporting of animal viral diseases. My reports form the basis upon which disease control strategies are developed. It is, therefore, of the utmost importance that these reports refl ect the true picture of the disease situation in the country, from which appropriate disease control policies and strategies can be derived.

Like in most developing countries, poultry farming in Kenya is mainly in the hands of the smallholder rural poor, mostly women and young people, and is usually the only livelihood source for smallholder farmers. Outbreaks of infectious viral diseases that cannot be treated pose a major constraint on poultry production. Vaccination is the recommended method of control for these diseases. But vaccines do not always prevent occurrence of a disease.

The apparent failure of vaccines to protect chicken from infectious bursal disease (IBD) got me interested in understanding the cause of the disease despite prompt vaccinations by farmers (IBD causes immune suppression, making chicken more prone to other infectious diseases). I wanted to improve my understanding of the epidemiology of IBD in Kenya, starting with the comparative molecular characterization of the circulating viruses with the currently used vaccine virus strains.

The facilities available at the central veterinary laboratory are suitable for carrying out basic molecular analysis. However, to undertake more advanced molecular research required to gain a better understanding of IBD viruses circulating in Kenya, I needed access to the facilities at the BecAILR Hub. Under the mentorship of the BecA-ILRI Hub scientists, in a very conducive research environment as an ABCF fellow, I learned many skills, including sequence editing and analysis, primer design, scientific paper writing and communicating science to non-scientists. These crosscutting skills will be very useful in improving my diagnostic capacity, and ultimately, scientific data collection for policy development at the DVS.

Based on the feedback and recommendations I gave to the DVS director, I am confident my research findings will form the basis for developing effective IBD control strategies, including diagnosis, vaccination, hatchery surveillance and certification, IBD vaccines registration and vaccine production. Implementation of such strategies will have far reaching impacts on poultry production, poverty alleviation, nutritional security, economic empowerment for women and young people, and self-employment. Reducing antimicrobial residues in poultry products will also contribute to a reduction in antimicrobial drug resistance in humans.

With my newly acquired skills, I will be able to contribute more to livestock research: science, technology and innovation. I am a better mentor to young people, a better leader and manager, a more fulfilled person, and, above all, an asset to my country. My time as an ABCF fellow marked the beginning of what I believe will be a journey full of discoveries, networking, research development and fulfilment.

Read more about the bioscience research and innovations that underpin development outcomes in the BecA-ILRI Hub 2016 Annual Report.

Investigating the role of bushmeat in the transmission of zoonotic diseases in Tanzania

Research conducted by the Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub in collaboration with National Health Laboratory of the Tanzania Ministry of Health and Social Welfare; Nelson Mandela African Institution of Science and Technology (NM-AIST); Sokoine University of Agriculture; Tanzania National Parks; Tanzania Wildlife Research Institute; Frankfurt Zoological Society; and Pennsylvania State University.

An outcome of the BecA-ILRI Hub’s Swedish funded initiative to strengthen infrastructural and human capability at NM-AIST, was the awarding of a grant to the institution by the US Defense Threat Reduction Agency.

The NM-AIST School of Life Sciences and Bioengineering and a consortium of partners including the BecA-ILRI Hub received a grant to investigate the role of bushmeat in the transmission of six pathogens between animals and humans in Tanzania.

An interdisciplinary and multi-institutional team of scientists from Tanzania, Kenya and the US are using state-of-the-art techniques to map the distribution of anthrax, ebola, marburg and monkeypox viruses as well as Brucella and Coxiella in bushmeat in Tanzania. The team assesses the biological risk and potential for impact on human health from these diseases.

The BecA-ILRI Hub provides capacity building, expertise and technology for the microbiome component of the project using the genomics platform. During a week-long workshop facilitated by the BecA-ILRI Hub at NM-AIST, Francesca Stomeo provided training on the theory and practice of the genomics pipeline to be used in the project.

Read more about the bioscience research and innovations that underpin development outcomes in the BecA-ILRI Hub 2016 Annual Report.

Research implemented in Kenya and Rwanda by the Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub and national partners — the Kenya Agricultural and Livestock Research Organization (KALRO) and  Rwanda Agriculture Board (RAB)

On-farm evaluations in Kenya and Rwanda have confirmed that the use of Brachiaria grass extends forage availability for livestock by up to three dry months. These evaluations also confirmed previous observations of increases in milk production and weight when cattle are fed on Brachiaria grass. Over 6,000 farmers in both countries are growing the four best-bet Brachiaria varieties (Basilisk, MG4, Piatã and Xaraés), which were identified through the use of a participatory approach with key stakeholders. These varieties are being concurrently scaled out in Kenya and Mali by the Accelerated Value Chain Development (AVDD) dairy project, funded by the United States Agency for International Development (USAID) Feed the Future Initiative. There is growing interest and a push to adopt Brachiaria grasses in other countries including Botswana, Cameroon, Mozambique, Namibia and Somalia.

This research has identified potentially beneficial bacteria that occur naturally within the grass (bacterial endophytes). The endophytes could be useful: increasing production of hormones that regulate: plant growth and boost biomass production in Brachiaria; improving soil nutrient solubility and soil fertility; enhancing drought tolerance; and improving the overall health of the grass. These endophytes are currently being evaluated under greenhouse conditions for their ability to confer drought tolerance to Brachiaria.

To ensure the transfer of technologies to national programs, seven researchers from five East African countries were trained on forages biotechnology through the Brachiaria program. After periods of between six and nine months at the BecA-ILRI Hub the NARS researchers returned to their home institutions with transferable skills acquired through the training. An in-depth external review of the program concluded that it has made significant contributions to the improvement of forage availability and livestock productivity in the aforementioned program countries.

Read more about the bioscience research and innovations that underpin development outcomes in the BecA-ILRI Hub 2016 Annual Report.

Blessing Adanta (left) and Lyna Mukwa at the BecA-ILRI Hub (photo: BecA-ILRI Hub/Eleni Vikeli)

This year, we celebrate Blessing Adanta, Jane Githinji and Lyna Mukwa who were awarded the Africa Biosciences Challenge Fund (ABCF) fellowship to conduct their research at the BecA-ILRI Hub. The ABCF fellowship is a competitive fellowship program that develops capacity for agricultural biosciences research in Africa, to support research for development projects that ultimately contribute towards increasing food and nutritional security and/or food safety in Africa.

Eleni Vikeli, PhD researcher at the John Innes Centre (UK) and Communications Assistant in BecA-ILRI Hub, interviewed the three women about the joys and challenges of being a scientist.

Blessing Adanta is a lecturer at the University of Port Harcourt in Nigeria and a PhD student of Plant Breeding and Biotechnology at Makerere University, Uganda  funded by the Regional Universities Forum for Capacity Building in Agriculture (RUFORUM) and the Carnegie cooperation, USA. In 2014, she won the African Women in Agricultural Research and Development (AWARD) and the 2014 fall Norman Borlaug Leadership Enhancement in Agriculture Programme (LEAP) fellowships.

Jane Githinji is the Assistant Director of Veterinary Services in Kenya. In 2016, her research on chicken vaccines conducted through the ABCF program, lent weight to the development of policies to guide the production of vaccines for Infectious bursal disease in Kenya.

Lyna Mukwa is an Associate Professor at the University of Kwango in the Democratic Republic of the Congo (DRC). She is also the director of the Plant Clinic of Kinshasa, a project jointly initiated by the Faculty of Agronomy of the University of Kinshasa and the Université Catholique de Louvain (Belgium), with the local support of the Agronomic and Veterinary Centre in Tropical Agriculture (CAVTK).

What has been the biggest challenge of your career so far?

Jane Githinji, Assistant Director of Veterinary Services in Kenya and ABCF alumnus

Blessing:The biggest challenge I have encountered so far, was when I left my hometown to pursue a PhD career, while I had my daughter with me. Try having long hours in the lab and teaching students with an active toddler waiting–I am very grateful for the support of my husband through all this!

Jane: My biggest challenge has been balancing between multiple roles–as a mother, a wife, a sibling, a manager, a friend, a scientist–in such a way that I remain effective in each one of them, and without losing my peace of mind!

Lyna: The hardest thing I had to do and am still trying to tackle is maintaining a balance between my professional and personal life. While trying to cope, I learned multiple ways to organise myself and organise everything!

What is your biggest reward from being a scientist?

Blessing:  I was privileged to have been given the opportunity as an AWARD fellow, to have mentors from different countries, senior scientists with great experience and qualifications. That enhanced my skills and filled me with confidence that I use in my own teaching sessions. On top of that, I feel lucky that my profession gave me the opportunity to travel and see the world beyond my country.

Jane: Just knowing that I am contributing to making the world a better and a happier place for someone is very fulfilling. I believe I am in this world for a good purpose–to make it a better and a happier world for someone.

Lyna: In my case, the biggest reward has been the interaction with students where I can share my knowledge and expertise. I am also proud of my published work which makes me a part of the scientific community and has allowed me to work in various institutions in three different countries.

What would you say is your biggest accomplishment?

Blessing: That would be the award I received in 2015 from my home institution, University of Port Harcourt in Nigeria in recognition of my contribution to science. I felt honoured and that all my hard work and sacrifice had paid off!

Jane: I consider successfully completing my ABCF fellowship at the BecA-ILRI Hub despite the initial challenges and being able to apply my research to policy, my biggest accomplishment. It was a test of my faith, patience, and will power.

Lyna: My biggest accomplishment is getting my PhD last November and shortly after that, I was appointed Associate Professor. This was definitely a dream of mine for quite a while and I felt wonderful when I accomplished it!

The three women cherish their roles as science leaders in Africa deeply despite the challenges it brings to their daily lives. To all the girls that dream of becoming the next Marie Curie, Rosalind Franklin or Ada Lovelace, they have proved that a woman can have a family as well as a career in science. They have overcome challenges, followed their passion and are making a difference in society.

Happy International Women’s Day 2017!

Article written by Eleni Vikeli, PhD researcher at the John Innes Centre (JIC), UK. Vikeli is at the BecA-ILRI Hub in Nairobi, Kenya as a communications assistant under the BecA-JIC alliance which supports capacity building, resource mobilization and technology transfer activities.

Read more about the BecA-JIC alliance: John Innes Centre forms research and capacity building alliance with the BecA-ILRI Hub

Cattle at a livestock market in eastern Kenya. Over one million cattle die of East Coast fever each year resulting in annual losses exceeding $300 million (photo: ILRI/Susan MacMillan)

As part of ongoing research to develop an effective vaccine for East Coast Fever (ECF), I conducted a study on the interactions between the parasites that cause disease and vectors that transmit them. East Coast Fever is a tick-borne disease that kills over 1 million cattle in East, Central and Southern Africa annually, devastating the livelihoods of smallholder livestock farmers. I would like to develop a vaccine that can block transmission of this disease at the vector level.

My quest to apply computational methods to identify potential ECF vaccine candidates however requires a more in-depth understanding of parasite and vector biology, and interaction. A travel scholarship from the BecA-ILRI Hub enabled me attend the 2016, the NIH-Global Infectious Disease Training Program’s Workshop on Biology of Parasites and Disease Vectors. This presented an opportunity to progress my search for a solution to ECF which begun through a fellowship under the Africa Biosciences Challenge Fund (ABCF) program at the BecA-ILRI Hub (October 2014–March 2015).

The workshop took place at Gulu University in Uganda, one of the regional institutions whose capacity has been strengthened by the BecA-ILRI Hub. It was organized by Gulu University in partnership with Yale University and Biotechnology Research Institute-Kenya Agricultural and Livestock Research Organization (BRI-KALRO). It was a good opportunity to share the outcome of my work, build my capacity and network with fellow researchers that share similar interests.

I gained different perspectives to approaching my research. For instance, I learned how  vector physiology, ecology, immunity, evolutionary biology and genetics studies are applied in development of effective disease control strategies. Through group discussions, I got new ideas for future ECF vaccine development studies.

Of course, at the end of the workshop, I gave a brief oral presentation about the BecA-ILRI Hub, and the opportunities available for African scientists to build their research capacity while solving major food insecurity causes such as livestock diseases on the continent.

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Read related story by Milcah Kigoni: Opportunities In Research And Beyond: The Africa Biosciences Challenge Fund Fellowship Program

Anne Muiruri – APTECA program coordinator at the BecA-ILRI Hub (photo: BecA-ILRI Hub/Alnoor Abdulla)

The Aflatoxin Proficiency Testing and Control in Africa (APTECA) program hosted by the mycotoxin diagnostics platform at the Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub is contributing to the availability of safe maize on the African market.

The program, managed by the Texas A&M University, USA, was initiated to support the commercial maize milling sector in Kenya through a public-private partnership. Cereal millers which participate in the voluntary program manage aflatoxin risk by improving their quality systems to accurately perform their own tests for aflatoxins in maize flour.

Proficiency testing program

Participation in the APTECA program improves testing accuracy through qualification of the mill’s laboratory analysts; use of working controls with a known level of aflatoxin; routine proficiency testing; and verification of mill results by the ISO accredited Texas A&M AgriLife laboratory housed at the BecA-ILRI Hub.

In 2015, 31 laboratory analysts from commercial mills across Kenya attended training and qualified to analyse maize flour using validated aflatoxin testing platforms. These qualified individuals analyse working control samples twice a week at their respective mills to ensure testing accuracy and results are evaluated using a statistical process control charting technique. Further verification of mills’ aflatoxin test results of finished product occurs at the Texas A&M AgriLife laboratory at the BecA-ILRI Hub and results are sent to the APTECA mills to assist in quality improvement and aflatoxin risk management.

Already, APTECA has hosted five proficiency testing exercises involving 30 industry and public sector laboratories. The companies involved in the project include Osho Grain Millers; Unga Holdings; Alpha Mills; Capwell Industries; Kabansora Millers; Kenblest Group; Maisha Flour Mills; Mombasa Maize Millers; Pembe Flour Mills; Premier Group; and United Millers all from Kenya.

Co-regulation

The APTECA research is part of an effort to explore co-regulation of aflatoxin as a regulatory risk-management policy alternative with the aim of improving food safety and facilitating trade in Africa. Co-regulation involves a government-private sector partnership in regulation that includes statutory or government-backed codes of practice combined with regulatory and industry oversight. A marketing study conducted by the International Food Policy Research Institute (IFPRI) and the Western Michigan University in collaboration with Texas A&M AgriLife explored the impact on sales of marketing products branded with a logo on packages of maize meal stating ‘Aflatoxin Tested Process Verified by APTECA.’ This logo conforms to the East African Community labelling requirements and AgriLife has received trademark approval for it from the Kenya Intellectual Property Institute.

A memorandum of understanding (MoU) with a Kenya regulatory authority, accreditation of the AgriLife laboratory activities by the Kenya Accreditation Service, and training regulatory chemists from six countries and nine agencies has helped lay the groundwork for a regional public-private sector partnership to manage aflatoxin risk and facilitate trade among countries in the Common Market for Eastern and Southern Africa.

The partnership brings together the Kenya Cereal Millers Association—which has over ten million customers, including the urban poor—and the Texas A&M AgriLife laboratory which is hosted at the BecA-ILRI Hub. It is enabling millers to accurately perform their own tests for aflatoxins in maize flour, reducing aflatoxin risk and improving food safety for an estimated 16 million Kenyans.

Aflatoxins are a naturally occurring carcinogenic by-product of common fungi that grow on grains and other food crops, particularly maize and groundnuts. Highly carcinogenic, aflatoxins are lethal in high doses, with chronic exposure potentially stunting infant development, blocking nutrient absorption and suppressing the immune system.

Preventing human exposure to aflatoxins involves removing crops with unacceptable aflatoxin contents from both foods and feeds.

Paloma Fernandes, the chief executive of the Kenya Cereal Millers Association, will give a presentation on industry-led approaches to controlling aflatoxin in the country’s food supply chain at the ‘Strengthening systems to optimize agriculture and nutrition outcomes in Africa’ side event.

Read event concept note: Strengthening Systems to Optimize Agriculture and Nutrition Outcomes in Africa

For more information on the Africa Agriculture Science Week visit: http://faraafrica.org/aasw7/

Follow the event on twitter: #AASW7

Read related articles:

A vision for safe, affordable and adequate food

Providing safe maize for Africa: Aflatoxin Proficiency Testing and Control in Africa project at the BecA-ILRI Hub

Regional Aflatoxin control organization recognizes role of the BecA-ILRI Hub in fighting aflatoxins

Having a milling capacity of 1.6 million tonnes of maize per year and constituting 85 percent of the commercial flour on the shelves sold to about 10 million consumers annually, the Cereal Millers Association (CMA) bears the heavy responsibility of providing safe, affordable and adequate food for their consumers. This responsibility is at the heart of our vision as an association which comprises 27 of the largest millers in the country.

Our four-year relationship with the BecA-ILRI Hub’s aflatoxin research project was borne out of our quest to bridge the existing gap in best practices for diagnosis of aflatoxins at the millers’ level. In efforts to find a solution, we participated in various national forums on the control of aflatoxins in the food value chain in Kenya and eventually made the connection with the project.

Through our collaboration with the BecA-ILRI Hub, CMA staff members have received training on the proper use of aflatoxin diagnostics equipment to get the most accurate results.Visits by the BecA-ILRI Hub scientists, research technicians and project collaborators to three CMA mills has helped us ascertain the levels of testing, training needs and ways in which we can improve our storage, transport and testing facilities.

In order for us to take adequate measures in providing safe food for Kenyans, we have extended
our collaboration to exploratory research on the types of aflatoxins we are dealing with at our mills and will provide samples of both wheat and maize to the BecA-ILRI Hub for analysis.

Through this partnership, we have also identified a consultant from Texas A&M University, USA, to
develop and test the feasibility of maize sampling and aflatoxin testing protocols for use in Kenyan maize mills – an initiative in which many of our mills are involved.

The dream of CMA is to have a fully-fledged laboratory for testing of aflatoxins and we believe with the support of research institutions like the BecA-ILRI Hub, this dream is not very distant. Ultimately we hope that we can achieve our goal to provide safe, affordable and adequate food for all our consumers.

On 24 June 2015, the BecA-ILRI Hub team and Africa Biosciences Challenge Fund (ABCF) fellows from across eastern and central Africa celebrated six-month old baby Rayan BecA Babiker.
Baby BecA who was born to ABCF fellow Rasha Adam from Sudan and her husband Babiker Mohammed is a testimony to the significance that the BecA-ILRI Hub places on supporting women in agricultural research.

Adam, a researcher at the Biotechnology and Biosafety Research Centre at the Agricultural Research Corporation (ARC) in Khartoum, Sudan joined the BecA-ILRI Hub on 30June 2014 for a year-long placement. Already expectant when she got her letter of acceptance to the highly competitive fellowship program, Adam was not willing to postpone her quest to improve the food security situation in Sudan despite being offered a postponement of the start date till after delivery. The BecA-ILRI Hub capacity building team worked with her to ensure her work-plan guaranteed her safety and comfort, and she commenced her placement in June 2014 as scheduled.

‘I am so grateful to all of you at the BecA-ILRI Hub for the support that you gave me throughout my pregnancy,’ said Adam, who gave her baby the name BecA as a reminder of the team that stood with her during a significant period in her career and family life.

In appreciating her co-ABCF fellows, Adam said ‘The ABCF fellows have become like family to me, watching over me throughout my pregnancy and showing me how to hold and care for the baby when she came.’

Appolinaire Djikeng, the director of the BecA-ILRI Hub lauded Rasha as a true example of the resilience of women in science.

‘It is inspiring to see Rasha balance her new status as a mother while conducting excellent science,’ said Djikeng. ‘Rasha is evidence of the heights that women can achieve when they are offered the right support,’ he added.

For the past one year, Rasha Adam has been working to optimize tissue culture and transformation protocols that will facilitate the enhancement of sweet sorghum for drought resistance. Sorghum is an important staple crop in Sudan due to its tolerance to high temperatures and drought. The sweet sorghum is increasingly significant in the country for its use as food, livestock feed and its potential for production of biofuels.

The research being conducted by this first time mother could result in the ground-breaking development of the very first protocol for the transformation of cereals.

For more pictures, visit the Flickr Album: Celebrating Baby BecA

Click here to view the embedded video.

Preliminary data from dairy farmers participating in on-farm evaluations of Brachiaria grasses in Kenya shows that the nutritious grasses contribute to increased milk production.

The on-going research program on Climate-smart Brachiaria Grasses to Increase  Livestock Production in East Africa conducted by the BecA-ILRI Hub in collaboration with the Kenya Agricultural and Livestock Research Institute (KALRO); Rwanda Agriculture Board (RAB) ; International Center for Tropical Agriculture (CIAT), Colombia; and Grasslanz Technology Limited, New Zealand has engaged smallholder farmers in cultivating the grasses as major livestock feed sources and as a source of household cash income through the seed production.

The Swedish funded program has been successful in, together with farmers, identifying best bet varieties for different agro-ecological regions and creating awareness among the farmers, researchers, extension agents, policy makers and politicians on the significance of Brachiaria grasses to support a growing dairy industry. Through the project, farmers have discovered that the Brachiaria grasses not only preferred by animals but  also grow better than most forage in marginal soils of semi-arid and sub-humid environments that are common in most of Sub-Saharan Africa.

In this four minute video, K24 journalist Violet Otindo talks to Albanus Nduva from Kanzalu village of Machakos County in eastern Kenya, one of the 1200 farmers in Kenya who have been involved in participatory on-farm evaluations of Brachiaria grasses as pasture and recording the milk production data Otindo also gets insights from BecA-ILRI Hub scientist Sita Ghimire who leads the program and Donald Njarui from KALRO, Kenya as to why Brachiaria grasses are good for the environment.

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Read related stories:

• Exploring Brachiaria the “wonder grass” in eastern Africa
• Welcome home Brachiaria! Home coming of Africa’s “super” grass
• Climate-smart Brachiaria Grasses: livestock feed, household cash