Category Archives: Research

Leveraging institutional networks to advance the search for East coast fever disease vaccine

Written by Milcah Kigoni – Africa Biosciences Challenge Fund fellowship program alumni

Cattle at a livestock market in eastern Kenya. Over one million cattle die of East Coast fever each year resulting in annual losses exceeding $300 million (photo: ILRI/Susan MacMillan)

As part of ongoing research to develop an effective vaccine for East Coast Fever (ECF), I conducted a study on the interactions between the parasites that cause disease and vectors that transmit them. East Coast Fever is a tick-borne disease that kills over 1 million cattle in East, Central and Southern Africa annually, devastating the livelihoods of smallholder livestock farmers. I would like to develop a vaccine that can block transmission of this disease at the vector level.

My quest to apply computational methods to identify potential ECF vaccine candidates however requires a more in-depth understanding of parasite and vector biology, and interaction. A travel scholarship from the BecA-ILRI Hub enabled me attend the 2016, the NIH-Global Infectious Disease Training Program’s Workshop on Biology of Parasites and Disease Vectors. This presented an opportunity to progress my search for a solution to ECF which begun through a fellowship under the Africa Biosciences Challenge Fund (ABCF) program at the BecA-ILRI Hub (October 2014–March 2015).

The workshop took place at Gulu University in Uganda, one of the regional institutions whose capacity has been strengthened by the BecA-ILRI Hub. It was organized by Gulu University in partnership with Yale University and Biotechnology Research Institute-Kenya Agricultural and Livestock Research Organization (BRI-KALRO). It was a good opportunity to share the outcome of my work, build my capacity and network with fellow researchers that share similar interests.

I gained different perspectives to approaching my research. For instance, I learned how vector physiology, ecology, immunity, evolutionary biology and genetics studies are applied in development of effective disease control strategies. Through group discussions, I got new ideas for future ECF vaccine development studies.

Of course, at the end of the workshop, I gave a brief oral presentation about the BecA-ILRI Hub, and the opportunities available for African scientists to build their research capacity while solving major food insecurity causes such as livestock diseases on the continent.

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Providing safe maize for Africa: Aflatoxin Proficiency Testing and Control in Africa project at the BecA-ILRI Hub

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By Tim Herrman, Texas state chemist, Texas A&M AgriLife

Anne Muiruri - APTECA (photo: BecA-ILRI Hub/Alnoor Abdulla)

Anne Muiruri – APTECA program coordinator at the BecA-ILRI Hub (photo: BecA-ILRI Hub/Alnoor Abdulla)

The Aflatoxin Proficiency Testing and Control in Africa (APTECA) program hosted by the mycotoxin diagnostics platform at the Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub is contributing to the availability of safe maize on the African market.

The program, managed by the Texas A&M University, USA, was initiated to support the commercial maize milling sector in Kenya through a public-private partnership. Cereal millers which participate in the voluntary program manage aflatoxin risk by improving their quality systems to accurately perform their own tests for aflatoxins in maize flour.

Proficiency testing program

Participation in the APTECA program improves testing accuracy through qualification of the mill’s laboratory analysts; use of working controls with a known level of aflatoxin; routine proficiency testing; and verification of mill results by the ISO accredited Texas A&M AgriLife laboratory housed at the BecA-ILRI Hub.

In 2015, 31 laboratory analysts from commercial mills across Kenya attended training and qualified to analyse maize flour using validated aflatoxin testing platforms. These qualified individuals analyse working control samples twice a week at their respective mills to ensure testing accuracy and results are evaluated using a statistical process control charting technique. Further verification of mills’ aflatoxin test results of finished product occurs at the Texas A&M AgriLife laboratory at the BecA-ILRI Hub and results are sent to the APTECA mills to assist in quality improvement and aflatoxin risk management.

Already, APTECA has hosted five proficiency testing exercises involving 30 industry and public sector laboratories. The companies involved in the project include Osho Grain Millers; Unga Holdings; Alpha Mills; Capwell Industries; Kabansora Millers; Kenblest Group; Maisha Flour Mills; Mombasa Maize Millers; Pembe Flour Mills; Premier Group; and United Millers all from Kenya.

Co-regulation

The APTECA research is part of an effort to explore co-regulation of aflatoxin as a regulatory risk-management policy alternative with the aim of improving food safety and facilitating trade in Africa. Co-regulation involves a government-private sector partnership in regulation that includes statutory or government-backed codes of practice combined with regulatory and industry oversight. A marketing study conducted by the International Food Policy Research Institute (IFPRI) and the Western Michigan University in collaboration with Texas A&M AgriLife explored the impact on sales of marketing products branded with a logo on packages of maize meal stating ‘Aflatoxin Tested Process Verified by APTECA.’ This logo conforms to the East African Community labelling requirements and AgriLife has received trademark approval for it from the Kenya Intellectual Property Institute.

A memorandum of understanding (MoU) with a Kenya regulatory authority, accreditation of the AgriLife laboratory activities by the Kenya Accreditation Service, and training regulatory chemists from six countries and nine agencies has helped lay the groundwork for a regional public-private sector partnership to manage aflatoxin risk and facilitate trade among countries in the Common Market for Eastern and Southern Africa.

Public-private partnership for food and nutrition security: BecA-ILRI Hub–Cereal Millers Association collaboration features at continental agricultural forum

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A partnership catalyzed by the Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub to improve testing for aflatoxins in maize flour will feature at a side event during the 7th Africa Agriculture Science Week and the Forum for Agricultural Research in Africa (FARA) general assembly, next week (from 13-14 June 2016).

The partnership brings together the Kenya Cereal Millers Association—which has over ten million customers, including the urban poor—and the Texas A&M AgriLife laboratory which is hosted at the BecA-ILRI Hub. It is enabling millers to accurately perform their own tests for aflatoxins in maize flour, reducing aflatoxin risk and improving food safety for an estimated 16 million Kenyans.

Aflatoxins are a naturally occurring carcinogenic by-product of common fungi that grow on grains and other food crops, particularly maize and groundnuts. Highly carcinogenic, aflatoxins are lethal in high doses, with chronic exposure potentially stunting infant development, blocking nutrient absorption and suppressing the immune system.

Preventing human exposure to aflatoxins involves removing crops with unacceptable aflatoxin contents from both foods and feeds.

Paloma Fernandes, the chief executive of the Kenya Cereal Millers Association, will give a presentation on industry-led approaches to controlling aflatoxin in the country’s food supply chain at the ‘Strengthening systems to optimize agriculture and nutrition outcomes in Africa’ side event.

Read event concept note: Strengthening Systems to Optimize Agriculture and Nutrition Outcomes in Africa

For more information on the Africa Agriculture Science Week visit: http://faraafrica.org/aasw7/

Follow the event on twitter: #AASW7

Read related articles:

A vision for safe, affordable and adequate food

Providing safe maize for Africa: Aflatoxin Proficiency Testing and Control in Africa project at the BecA-ILRI Hub

Regional Aflatoxin control organization recognizes role of the BecA-ILRI Hub in fighting aflatoxins

A vision for safe, affordable and adequate food – Kenya Cereal Millers Association collaborates with BecA-ILRI Hub to combat aflatoxin contamination

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By Paloma Fernandes, CEO of the Kenya Cereal Millers Association

Having a milling capacity of 1.6 million tonnes of maize per year and constituting 85 percent of the commercial flour on the shelves sold to about 10 million consumers annually, the Cereal Millers Association (CMA) bears the heavy responsibility of providing safe, affordable and adequate food for their consumers. This responsibility is at the heart of our vision as an association which comprises 27 of the largest millers in the country.

Our four-year relationship with the BecA-ILRI Hub’s aflatoxin research project was borne out of our quest to bridge the existing gap in best practices for diagnosis of aflatoxins at the millers’ level. In efforts to find a solution, we participated in various national forums on the control of aflatoxins in the food value chain in Kenya and eventually made the connection with the project.

Through our collaboration with the BecA-ILRI Hub, CMA staff members have received training on the proper use of aflatoxin diagnostics equipment to get the most accurate results.Visits by the BecA-ILRI Hub scientists, research technicians and project collaborators to three CMA mills has helped us ascertain the levels of testing, training needs and ways in which we can improve our storage, transport and testing facilities.

In order for us to take adequate measures in providing safe food for Kenyans, we have extended
our collaboration to exploratory research on the types of aflatoxins we are dealing with at our mills and will provide samples of both wheat and maize to the BecA-ILRI Hub for analysis.

Through this partnership, we have also identified a consultant from Texas A&M University, USA, to
develop and test the feasibility of maize sampling and aflatoxin testing protocols for use in Kenyan maize mills – an initiative in which many of our mills are involved.

The dream of CMA is to have a fully-fledged laboratory for testing of aflatoxins and we believe with the support of research institutions like the BecA-ILRI Hub, this dream is not very distant. Ultimately we hope that we can achieve our goal to provide safe, affordable and adequate food for all our consumers.

Bioscience hub cited among strategic investments for improved livelihoods in Africa by BMGF and DFID

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Jacqueline Kasiiti Lichoti from the Kenyan Ministry of Livestock (a key member of the BecA-led African swine fever research team) explains biosecurity measures to pig farmer in Busia, Kenya (photo: BecA-ILRI Hub/Larelle McMillan)

Jacqueline Kasiiti Lichoti from the Kenyan Ministry of Livestock, a key member of the BecA-led African swine fever research project, explains bio-security measures to pig farmer in Busia, Kenya (photo: BecA-ILRI Hub/Larelle McMillan)

Extreme poverty can be ended by putting science at the centre of international development. These are the thoughts of Sue Desmond-Hellmann, CEO of the Bill & Melinda Gates Foundation (BMGF), and Nick Hurd, international development minister for Britain’s Department for International Development (DFID).

In an article written for the Guardian’s Global Development blog on 16 March 2016, Hellman and Hurd articulate how joint investments by BMGF and DFID are already contributing to improving lives globally.

The article cites support to the Biosciences eastern and central Africa-ILRI Hub (BecA-ILRI Hub) which provides access to cutting-edge facilities by crop and livestock scientists from over 18 African countries. This support has also facilitated the creation of triangular alliances between the BecA-ILRI Hub, African national agricultural research systems and advanced international research institutions, bringing to bear the most advanced knowledge and technology to smallholder farmers’ fields in Africa.

Hellman and Hurd also highlight joint support to a partnership for livestock veterinary medicines, the Global Alliance for Livestock Veterinary Medicines (GALVmed), in which ILRI is a major partner. Through GALVmed, ILRI is helping livestock-keeping communities in Africa to access a vaccine against East Coast fever, the lethal cattle disease endemic in 11 countries of eastern, central and southern Africa.

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Read the whole article by Sue Desmond-Hellmann, CEO of the Bill & Melinda Gates Foundation, and Nick Hurd, the international development minister for Britain’s Department for International Development in the Guardian’s Global Development blog: To end poverty, put science at the heart of development, 16 Mar 2016.

Read a related article on the ILRI website: ILRI biosciences hub and vaccine development named global public goods by heads of BMGF and DFID

Get more about ILRI’s livestock vaccine platform on the ILVAC blog site.

Ugandan scientist awarded for research on ‘orphan crop’ yam

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When she chose to spend her sabbatical in 2014 conducting research at the BecA-ILRI Hub, Jacinta Akol from the National Crops Resources Research Institute in Uganda had no idea that this research would win her international awards.

Jacinta Akol receives the ‘Pat Coursey’ award from Keith Tomlins, president of the International Society for Tropical Root Crops (ISTRC). Looking on is Claude Fauqet, co-founder of the Global Cassava Partnership for the 21 Century (GCP2) (photo: WCRTC)

During the First World Congress on Root and Tuber Crops (RTCs) meeting that took place in China from 18–22 January 2016, Akol was awarded the Pat Coursey prize in recognition of her contribution to research on yams in Uganda.

The research done on this under-studied, underutilized food crop by Akol through an Africa Biosciences Challenge Fund fellowship. Akol reiterated the impact of the fellowship at the BecA-ILRI Hub in defining her scientific goals and giving her career more focus.

‘While at the Hub, I was able to sharpen my skills in networking, adoption of modern scientific techniques and most importantly effective communication,’ said Akol. ‘This has really boosted my confidence and profile as a scientist’ she added.

Akol stated that the BecA-ILRI Hub is an extremely significant investment in raising agricultural research in the region.

‘At the BecA-ILRI Hub, science leaders who will improve the face of agriculture in Africa are being created,’ she said. ‘It is important that African governments support such organizations which exist to support our national agricultural research systems,’ she added.

Root and tuber crops, including yams, cassava, sweet potato, potato, cocoyams and other root crops are important to agriculture and food security of more than 100 countries. In Uganda, yam is increasingly gaining importance as a source of income for smaller holder farmers.

The RTCs congress aims at raising awareness of the importance of the RTCs in the world. It reviews scientific progress; identifies new opportunities; and sets priorities to tackle challenges including finding the resources to support research and development in areas where it is currently inadequate or lacking.

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About the Africa Biosciences Challenge Fund

The Africa Biosciences Challenge Fund (ABCF), managed by the BecA-ILRI Hub, provides fellowships to scientists and graduate students from African national agricultural research systems to undertake biosciences research-for-development projects at the BecA-ILRI Hub. The ABCF fellowship program develops capacity for agricultural biosciences research in Africa; supports research projects that ultimately contribute towards increasing food and nutritional security or food safety in Africa; and facilitates access to cutting-edge research facilities by African researchers.

Defining the future of genomics in plant breeding

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Appolinaire Djikeng, director, the BecA-ILRI Hub speaks on the role of genomics in plant breeding

The availability of genomics tools is transforming plant breeding by making it possible to identify and capitalize on their positive genetic traits. Genomics, or the study of genes and their interrelationships and functions, is giving plant breeders the means to accelerate the development of new higher yielding crop varieties that are capable of withstanding pests, diseases, or climate changes, and ultimately improve the global status of food and nutritional security.

In this three-minute video, Appolinaire Djikeng, director of the Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub in Nairobi, Kenya gives his views on the future of genomics in breeding and why research programs should invest more in the acquisition and application of genomics tools.

The BecA-ILRI Hub, a joint initiative of the African Union’s New Partnership for Africa’s Development (AU/NEPAD) and ILRI, is strengthening the capacity of African scientists to exploit advances in research by providing access to technologies previously unavailable in the region. The BecA-ILRI Hub genomics platform actively supports a wide range of research projects in molecular breeding as well as animal, crop and environmental health. Through a continued collaboration with researchers from African national agricultural research systems, the genomics platform is helping guide the design of strategies for increased agricultural productivity and crop and livestock disease management in Africa.

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Read more about the BecA-ILRI Hub Technologies and research related services

Livestock, a lifeline for smallholder farmers: The BecA-ILRI Hub director to participate in IFAD AgTalks in Rome, Italy

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Approximately 95 per cent of livestock keepers live in extreme poverty despite the increased demand for animal products such as milk and meat. While it is recognized that livestock keeping offers a promising opportunity to combat poverty in many developing countries, most livestock policies and services tend to favour large-scale production.

Appolinaire Djikeng at the Annual Bioforsk Conference in Norway Join Appolinaire Djikeng, the Director of the Biosciences eastern and central Africa – International Livestock Research Institute (BecA-ILRI) Hub on 9 July 2015 during the fourth session of AgTalks as he gives his perspective on what it will take to reverse this trend.

Djikeng will be sharing his vision on why Africa’s untapped animal genetic diversity, particularly of mini livestock, holds the key to helping poor and vulnerable households in rural and peri-urban African climb up the livestock ladder out of poverty.

Djikeng is a strong proponent of capacity-building in Africa. His focus is on building the next generation of African scientists and tapping on bioscience to address agricultural development and public health issues. Djikeng has led the domestication of ruminant species in Africa, including the grasscutter, to create sustainable sources of protein.

Twitte handle: @BecAHub

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About AgTalks
As a contribution to the International Year of Family Farming (IYFF), the International Fund for Agricultural Development (IFAD), a specialized United Nations agency and the only international financial institution within the UN family, launched the AgTalks series. IFAD is exclusively dedicated to investing in rural people and working with smallholder family farmers. The objective of AgTalks is to present the human face of family farming by sharing the latest policy research findings, as well as different viewpoints on smallholder farming.

The fourth session of AgTalks brings together Appoliniare Djikeng,Director, BecA-ILRI Hub; Emma Naluyima, smallholder farmer and private veterinarian, Uganda; Robyn Alders, Associate Professor, University of Sydney and Director, KYEEMA Foundation; and Guillermo Vila Melo,agronomist engineer, who will share their perspectives and views on the critical importance of livestock to smallholder farmers

Follow the proceedings and interact with the prominent guests via webcasting.
Share your views and insights on social media with the #agtalks hashtag.

Providing much needed support to African women in science at the BecA-ILRI Hub

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The BecA-ILRI Hub fraternity celebrates visiting researcher’s family milestone

On 24 June 2015, the BecA-ILRI Hub team and Africa Biosciences Challenge Fund (ABCF) fellows from across eastern and central Africa celebrated six-month old baby Rayan BecA Babiker.
Baby BecA who was born to ABCF fellow Rasha Adam from Sudan and her husband Babiker Mohammed is a testimony to the significance that the BecA-ILRI Hub places on supporting women in agricultural research.

Africa Bioscience Challenge Fund Fellow Rasha Adam and her family pose with BecA-ILRI Hub communications officer Ethel Makila and capacity building officer Valerian Aloo, Nairobi, Kenya

Adam, a researcher at the Biotechnology and Biosafety Research Centre at the Agricultural Research Corporation (ARC) in Khartoum, Sudan joined the BecA-ILRI Hub on 30June 2014 for a year-long placement. Already expectant when she got her letter of acceptance to the highly competitive fellowship program, Adam was not willing to postpone her quest to improve the food security situation in Sudan despite being offered a postponement of the start date till after delivery. The BecA-ILRI Hub capacity building team worked with her to ensure her work-plan guaranteed her safety and comfort, and she commenced her placement in June 2014 as scheduled.

‘I am so grateful to all of you at the BecA-ILRI Hub for the support that you gave me throughout my pregnancy,’ said Adam, who gave her baby the name BecA as a reminder of the team that stood with her during a significant period in her career and family life.

In appreciating her co-ABCF fellows, Adam said ‘The ABCF fellows have become like family to me, watching over me throughout my pregnancy and showing me how to hold and care for the baby when she came.’

Appolinaire Djikeng, the director of the BecA-ILRI Hub lauded Rasha as a true example of the resilience of women in science.

‘It is inspiring to see Rasha balance her new status as a mother while conducting excellent science,’ said Djikeng. ‘Rasha is evidence of the heights that women can achieve when they are offered the right support,’ he added.

For the past one year, Rasha Adam has been working to optimize tissue culture and transformation protocols that will facilitate the enhancement of sweet sorghum for drought resistance. Sorghum is an important staple crop in Sudan due to its tolerance to high temperatures and drought. The sweet sorghum is increasingly significant in the country for its use as food, livestock feed and its potential for production of biofuels.

The research being conducted by this first time mother could result in the ground-breaking development of the very first protocol for the transformation of cereals.

For more pictures, visit the Flickr Album: Celebrating Baby BecA

Celebrating the woman who inspired me (2) – Anna Nagadya, my inspiration to innovate

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Celebrated by Alexander Bombom, lead project scientist for the sorghum-maize hybrid project at the BecA-ILRI Hub

The woman who has had the most influence on my life and growing career is Ms Anna Nagadya. Growing up with my grandma Anna on the large acres of coffee and banana she farmed for a living automatically made me love agriculture and nature.

When my great grandfather, Anna’s father, opted not to educate his daughters in favor of his sons (as was the tradition then), Anna strove to achieve a basic education. Despite dropping out of school at primary 2 (grade 2), Anna taught herself to read and write.

Alexandar Bombom (then in high school) and his grandmother Anna Nagadya

When Anna had her own daughter, she went against the norms and ensured my mother, Elizabeth Nandawula Ovuga, now a trained nurse, had a good education. Her determination to educate a girl child against all odds inspires me.

Anna’s passion for education did not stop at my mother. She always said to her grandchildren and especially the girls;

“Kumulembe guno, omukyala yena asana asomeko muleme kubera nga ffe. Mwongere ku degree gyemufunye, mu fune emirimu mubeko ne sente zamwe”

meaning,

“In the present times, unlike in our times, a woman too needs to have a good education. Don’t sit on your first degrees, but strive to study further, find jobs, have your own earnings and contribute to your homes”.

When chose agriculture as my bachelors degree, grandma Anna supported me in every way, sharing her traditional agricultural knowledge. In her last words to me before her passing, she said:

“Bombom, education is the basic gift you have received from your parents. Now use your innovation to put food on the tables of many, for many shall die of starvation if things continue as they are now ”.

With these words etched in my mind, how can I fight the desire to do something revolutionary that will save people’s lives? My dream now is to develop agricultural products that will be useful to the large population of smallholder farmers who are struggling to earn a decent living in Uganda and beyond!