Tag Archives: research

Leveraging institutional networks to advance the search for East coast fever disease vaccine

Written by Milcah Kigoni – Africa Biosciences Challenge Fund fellowship program alumni

Cattle at a livestock market in eastern Kenya. Over one million cattle die of East Coast fever each year resulting in annual losses exceeding $300 million (photo:  ILRI/Susan MacMillan)

Cattle at a livestock market in eastern Kenya. Over one million cattle die of East Coast fever each year resulting in annual losses exceeding $300 million (photo: ILRI/Susan MacMillan)

As part of ongoing research to develop an effective vaccine for East Coast Fever (ECF), I conducted a study on the interactions between the parasites that cause disease and vectors that transmit them. East Coast Fever is a tick-borne disease that kills over 1 million cattle in East, Central and Southern Africa annually, devastating the livelihoods of smallholder livestock farmers. I would like to develop a vaccine that can block transmission of this disease at the vector level.

My quest to apply computational methods to identify potential ECF vaccine candidates however requires a more in-depth understanding of parasite and vector biology, and interaction. A travel scholarship from the BecA-ILRI Hub enabled me attend the 2016, the NIH-Global Infectious Disease Training Program’s Workshop on Biology of Parasites and Disease Vectors. This presented an opportunity to progress my search for a solution to ECF which begun through a fellowship under the Africa Biosciences Challenge Fund (ABCF) program at the BecA-ILRI Hub (October 2014–March 2015).

The workshop took place at Gulu University in Uganda, one of the regional institutions whose capacity has been strengthened by the BecA-ILRI Hub. It was organized by Gulu University in partnership with Yale University and Biotechnology Research Institute-Kenya Agricultural and Livestock Research Organization (BRI-KALRO). It was a good opportunity to share the outcome of my work, build my capacity and network with fellow researchers that share similar interests.

I gained different perspectives to approaching my research. For instance, I learned how  vector physiology, ecology, immunity, evolutionary biology and genetics studies are applied in development of effective disease control strategies. Through group discussions, I got new ideas for future ECF vaccine development studies.

Of course, at the end of the workshop, I gave a brief oral presentation about the BecA-ILRI Hub, and the opportunities available for African scientists to build their research capacity while solving major food insecurity causes such as livestock diseases on the continent.

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Read related story by Milcah Kigoni: Opportunities In Research And Beyond: The Africa Biosciences Challenge Fund Fellowship Program

Cassava, flies and viruses: studying the role of whiteflies in cassava disease at the BecA-ILRI Hub

By William Sharpee, postdoctoral fellow, North Carolina State University

Gabriela Chavez and William Sharpee

Post-doctoral scientists Gabriela Chavez from Auburn University (left) and William Sharpee (2nd right) from North Carolina State University interact with cassava farmers in the western region of Kenya during a whitefly collecting exercise

Cassava is an important food crop for millions of people in sub-Saharan Africa, but unfortunately this crop is facing a decline in production across the continent due to Cassava Mosaic Disease (CMD). I came to the BecA-ILRI Hub in August to work on a project funded by the National Science Foundation Partnerships for International Research and Education (NSF-PIRE) to analyze the evolution of the viruses that cause this disease.

The purpose of this project is to understand how African cassava mosaic virus (ACMV) and East African cassava mosaic virus (EACMV), the causal agents of CMD, evolve during vegetative propagation of infected cassava plants versus being transmitted via whiteflies. It is our goal to understand how these viruses evolve in order to develop strategies that will hinder the development of more virulent strains and thus prevent future outbreaks of CMD.

When I first arrived in Kenya, I travelled to the shores of Lake Victoria in the western part of Kenya to collect whiteflies for the establishment of a colony at the BecA-ILRI Hub. This was a good opportunity to interact with local farmers and see the devastating effects that this disease has on cassava production in Kenya. Once the individual whiteflies were collected we set up a room dedicated to establishing a colony to be used in future experiments.

Because multiple species of whiteflies exist, my colleagues and I have focused our efforts on understanding the genetic make up of the colony to ensure that we have a single species for our experiments. Additionally, we established procedures for the propagation and growth of cassava in the greenhouse. We continue to lay the groundwork for pilot experiments that will act as the basis for our future work.

I am excited to be a part of this project and the BecA-ILRI Hub community. I am grateful for everyone’s support and input and look forward to great discoveries in the future.

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Read related stories:

International partnership on Cassava virus evolution launched in Africa

Auburn University Post-Doc Tracks Cassava Virus History In East Africa

The BecA-ILRI Hub strengthens partnership with North Carolina State University

 

Providing safe maize for Africa: Aflatoxin Proficiency Testing and Control in Africa project at the BecA-ILRI Hub

By Tim Herrman, Texas state chemist, Texas A&M AgriLife

Anne Muiruri - APTECA (photo: BecA-ILRI Hub/Alnoor Abdulla)

Anne Muiruri – APTECA program coordinator at the BecA-ILRI Hub (photo: BecA-ILRI Hub/Alnoor Abdulla)

The Aflatoxin Proficiency Testing and Control in Africa (APTECA) program hosted by the mycotoxin diagnostics platform at the Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub is contributing to the availability of safe maize on the African market.

The program, managed by the Texas A&M University, USA, was initiated to support the commercial maize milling sector in Kenya through a public-private partnership. Cereal millers which participate in the voluntary program manage aflatoxin risk by improving their quality systems to accurately perform their own tests for aflatoxins in maize flour.

Proficiency testing program

Participation in the APTECA program improves testing accuracy through qualification of the mill’s laboratory analysts; use of working controls with a known level of aflatoxin; routine proficiency testing; and verification of mill results by the ISO accredited Texas A&M AgriLife laboratory housed at the BecA-ILRI Hub.

In 2015, 31 laboratory analysts from commercial mills across Kenya attended training and qualified to analyse maize flour using validated aflatoxin testing platforms. These qualified individuals analyse working control samples twice a week at their respective mills to ensure testing accuracy and results are evaluated using a statistical process control charting technique. Further verification of mills’ aflatoxin test results of finished product occurs at the Texas A&M AgriLife laboratory at the BecA-ILRI Hub and results are sent to the APTECA mills to assist in quality improvement and aflatoxin risk management.

Already, APTECA has hosted five proficiency testing exercises involving 30 industry and public sector laboratories. The companies involved in the project include Osho Grain Millers; Unga Holdings; Alpha Mills; Capwell Industries; Kabansora Millers; Kenblest Group; Maisha Flour Mills; Mombasa Maize Millers; Pembe Flour Mills; Premier Group; and United Millers all from Kenya.

Co-regulation

The APTECA research is part of an effort to explore co-regulation of aflatoxin as a regulatory risk-management policy alternative with the aim of improving food safety and facilitating trade in Africa. Co-regulation involves a government-private sector partnership in regulation that includes statutory or government-backed codes of practice combined with regulatory and industry oversight. A marketing study conducted by the International Food Policy Research Institute (IFPRI) and the Western Michigan University in collaboration with Texas A&M AgriLife explored the impact on sales of marketing products branded with a logo on packages of maize meal stating ‘Aflatoxin Tested Process Verified by APTECA.’ This logo conforms to the East African Community labelling requirements and AgriLife has received trademark approval for it from the Kenya Intellectual Property Institute.

A memorandum of understanding (MoU) with a Kenya regulatory authority, accreditation of the AgriLife laboratory activities by the Kenya Accreditation Service, and training regulatory chemists from six countries and nine agencies has helped lay the groundwork for a regional public-private sector partnership to manage aflatoxin risk and facilitate trade among countries in the Common Market for Eastern and Southern Africa.

Public-private partnership for food and nutrition security: BecA-ILRI Hub–Cereal Millers Association collaboration features at continental agricultural forum

A partnership catalyzed by the Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub to improve testing for aflatoxins in maize flour will feature at a side event during the 7th Africa Agriculture Science Week and the Forum for Agricultural Research in Africa (FARA) general assembly, next week (from 13-14 June 2016).

The partnership brings together the Kenya Cereal Millers Association—which has over ten million customers, including the urban poor—and the Texas A&M AgriLife laboratory which is hosted at the BecA-ILRI Hub. It is enabling millers to accurately perform their own tests for aflatoxins in maize flour, reducing aflatoxin risk and improving food safety for an estimated 16 million Kenyans.

Members of the Kenya Cereal Millers Association visit the BecA-ILRI Hub facilities

Aflatoxins are a naturally occurring carcinogenic by-product of common fungi that grow on grains and other food crops, particularly maize and groundnuts. Highly carcinogenic, aflatoxins are lethal in high doses, with chronic exposure potentially stunting infant development, blocking nutrient absorption and suppressing the immune system.

Preventing human exposure to aflatoxins involves removing crops with unacceptable aflatoxin contents from both foods and feeds.

Paloma Fernandes, the chief executive of the Kenya Cereal Millers Association, will give a presentation on industry-led approaches to controlling aflatoxin in the country’s food supply chain at the ‘Strengthening systems to optimize agriculture and nutrition outcomes in Africa’ side event.

Read event concept note: Strengthening Systems to Optimize Agriculture and Nutrition Outcomes in Africa

For more information on the Africa Agriculture Science Week visit: http://faraafrica.org/aasw7/

Follow the event on twitter: #AASW7

Read related articles:

A vision for safe, affordable and adequate food

Providing safe maize for Africa: Aflatoxin Proficiency Testing and Control in Africa project at the BecA-ILRI Hub

Regional Aflatoxin control organization recognizes role of the BecA-ILRI Hub in fighting aflatoxins

 

A vision for safe, affordable and adequate food – Kenya Cereal Millers Association collaborates with BecA-ILRI Hub to combat aflatoxin contamination

By Paloma Fernandes, CEO of the Kenya Cereal Millers Association

PalomaHaving a milling capacity of 1.6 million tonnes of maize per year and constituting 85 percent of the commercial flour on the shelves sold to about 10 million consumers annually, the Cereal Millers Association (CMA) bears the heavy responsibility of providing safe, affordable and adequate food for their consumers. This responsibility is at the heart of our vision as an association which comprises 27 of the largest millers in the country.

Our four-year relationship with the BecA-ILRI Hub’s aflatoxin research project was borne out of our quest to bridge the existing gap in best practices for diagnosis of aflatoxins at the millers’ level. In efforts to find a solution, we participated in various national forums on the control of aflatoxins in the food value chain in Kenya and eventually made the connection with the project.

Through our collaboration with the BecA-ILRI Hub, CMA staff members have received training on the proper use of aflatoxin diagnostics equipment to get the most accurate results.Visits by the BecA-ILRI Hub scientists, research technicians and project collaborators to three CMA mills has helped us ascertain the levels of testing, training needs and ways in which we can improve our storage, transport and testing facilities.

In order for us to take adequate measures in providing safe food for Kenyans, we have extended
our collaboration to exploratory research on the types of aflatoxins we are dealing with at our mills and will provide samples of both wheat and maize to the BecA-ILRI Hub for analysis.

Through this partnership, we have also identified a consultant from Texas A&M University, USA, to
develop and test the feasibility of maize sampling and aflatoxin testing protocols for use in Kenyan maize mills – an initiative in which many of our mills are involved.

The dream of CMA is to have a fully-fledged laboratory for testing of aflatoxins and we believe with the support of research institutions like the BecA-ILRI Hub, this dream is not very distant. Ultimately we hope that we can achieve our goal to provide safe, affordable and adequate food for all our consumers.

Bioscience hub cited among strategic investments for improved livelihoods in Africa by BMGF and DFID

Jacqueline Kasiiti Lichoti from the Kenyan Ministry of Livestock (a key member of the BecA-led African swine fever research team) explains biosecurity measures to pig farmer in Busia, Kenya (photo: BecA-ILRI Hub/Larelle McMillan)

Jacqueline Kasiiti Lichoti from the Kenyan Ministry of Livestock, a key member of the BecA-led African swine fever research project, explains bio-security measures to pig farmer in Busia, Kenya (photo: BecA-ILRI Hub/Larelle McMillan)

Extreme poverty can be ended by putting science at the centre of international development. These are the thoughts of Sue Desmond-Hellmann, CEO of the Bill & Melinda Gates Foundation (BMGF), and Nick Hurd, international development minister for Britain’s Department for International Development (DFID).

In an article written for the Guardian’s Global Development blog on 16 March 2016, Hellman and Hurd articulate how joint investments by BMGF and DFID are already contributing to improving lives globally.

The article cites support to the Biosciences eastern and central Africa-ILRI Hub (BecA-ILRI Hub) which provides access to cutting-edge facilities by crop and livestock scientists from over 18 African countries. This support has also facilitated the creation of triangular alliances between the BecA-ILRI Hub, African national agricultural research systems and advanced international research institutions, bringing to bear the most advanced knowledge and technology to smallholder farmers’ fields in Africa.

Hellman and Hurd also highlight joint support to a partnership for livestock veterinary medicines, the Global Alliance for Livestock Veterinary Medicines (GALVmed), in which ILRI is a major partner. Through GALVmed, ILRI is helping livestock-keeping communities in Africa to access a vaccine against East Coast fever, the lethal cattle disease endemic in 11 countries of eastern, central and southern Africa.

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Read the whole article by Sue Desmond-Hellmann, CEO of the Bill & Melinda Gates Foundation, and Nick Hurd, the international development minister for Britain’s Department for International Development in the Guardian’s Global Development blogTo end poverty, put science at the heart of development, 16 Mar 2016.

Read a related article on the ILRI website: ILRI biosciences hub and vaccine development named global public goods by heads of BMGF and DFID

Get more about ILRI’s livestock vaccine platform on the ILVAC blog site.

 

Ugandan scientist awarded for research on ‘orphan crop’ yam

When she chose to spend her sabbatical in 2014 conducting research at the BecA-ILRI Hub, Jacinta Akol from the National Crops Resources Research Institute in Uganda had no idea that this research would win her international awards.

Jacinta Akol receives the ‘Pat Coursey’ award from Keith Tomlins, president of the International Society for Tropical Root Crops (ISTRC). Looking on is Claude Fauqet, co-founder of the Global Cassava Partnership for the 21 Century (GCP2) (photo: WCRTC)

Jacinta Akol receives the ‘Pat Coursey’ award from Keith Tomlins, president of the International Society for Tropical Root Crops (ISTRC). Looking on is Claude Fauqet, co-founder of the Global Cassava Partnership for the 21 Century (GCP2) (photo: WCRTC)

During the First World Congress on Root and Tuber Crops (RTCs) meeting that took place in China from 18–22 January 2016, Akol was awarded the Pat Coursey prize in recognition of her contribution to research on yams in Uganda.

The research done on this under-studied, underutilized food crop by Akol through an Africa Biosciences Challenge Fund fellowship. Akol reiterated the impact of the fellowship at the BecA-ILRI Hub in defining her scientific goals and giving her career more focus.

‘While at the Hub, I was able to sharpen my skills in networking, adoption of modern scientific techniques and most importantly effective communication,’ said Akol. ‘This has really boosted my confidence and profile as a scientist’ she added.

Akol stated that the BecA-ILRI Hub is an extremely significant investment in raising agricultural research in the region.

‘At the BecA-ILRI Hub, science leaders who will improve the face of agriculture in Africa are being created,’ she said. ‘It is important that African governments support such organizations which exist to support our national agricultural research systems,’ she added.

Root and tuber crops, including yams, cassava, sweet potato, potato, cocoyams and other root crops are important to agriculture and food security of more than 100 countries. In Uganda, yam is increasingly gaining importance as a source of income for smaller holder farmers.

The RTCs congress aims at raising awareness of the importance of the RTCs in the world. It reviews scientific progress; identifies new opportunities; and sets priorities to tackle challenges including finding the resources to support research and development in areas where it is currently inadequate or lacking.

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About the Africa Biosciences Challenge Fund

The Africa Biosciences Challenge Fund (ABCF), managed by the BecA-ILRI Hub, provides fellowships to scientists and graduate students from African national agricultural research systems to undertake biosciences research-for-development projects at the BecA-ILRI Hub. The ABCF fellowship program develops capacity for agricultural biosciences research in Africa; supports research projects that ultimately contribute towards increasing food and nutritional security or food safety in Africa; and facilitates access to cutting-edge research facilities by African researchers.

International Women’s day 2016: Recognizing BecA-ILRI Hub women’s contribution to research in Africa

downloadThe United Nations Institute for Statistics’ reports show that only 28 per cent of the world’s researchers are women. It also reveals that many of the women who enroll for science careers in university end up choosing not to advance their science careers.

The scenario at the Biosciences eastern and central Africa-International Livestock research Institute (BecA-ILRI) Hub in Kenya is however quite different. With 50 percent female staff, the African centre for excellence in agricultural biosciences has proven that women do have a significant contribution to make to research for development in Africa and beyond.

As we celebrate the International Women’s day 2016, the BecA-ILRI Hub pays special tribute to all the women who are part of a dedicated team of scientists; technical staff; and administrators playing a vital role in empowering African scientists to use biosciences in transforming African agriculture.

In this article, you will meet two out of 22 remarkable women who represent the skill, passion and determination of women in science at the BecA-ILRI Hub and of many more across the globe.

Happy International Women’s Day!

Agnes Mburu
Technical management assistant

A trained electronics engineering technologist, Agnes is driven to ensure the efficient management and use of the electronic equipment at the shared research platform.

IMG_8478“I got the greatest encouragement in choosing a career in Electronics Engineering from my high school physics teacher. He had only two girls in his class—the other 38 opted to take geography instead.

I have a passion for all things ‘electricity’ and what I love most about my job is that I am always learning new things. But more important to me is the fact that as I learn, I am able to support researchers in the proper use of equipment to ensure their success.

Although mine is a male dominated field, this has never stopped me from being the best that I can be. Being open to new ideas and new ways of doing things has helped me overcome the negative attitudes I faced when I chose my career.

The greatest challenge I have faced is getting the resources to finance my learning and career growth. It was a tough choice to make—progressing my career while at the same time, providing for my family. What kept me strong is the understanding that whatever we do in life never goes unnoticed.

I plan to start a group to support the young people in my village who did not get an opportunity to go to high school. There are many opportunities for hands-on training at the polytechnics in Kenya which they can benefit from. Maybe given an opportunity, more women from my village will join my profession.”

Everline Atieno
Acting Central Core Unit Coordinator

Trained in laboratory technology and biotechnology, Everline manages a team providing essential services to all laboratory users at the BecA-ILRI Hub.

IMG_8448“I developed an interest in science at a very early age and therefore I had a bias towards science subjects in high school.

The most exciting thing about working at the BecA-ILRI Hub is that I am adding value to research done by national, regional and international scientists. I get to meet top notch scientists, students, research associates, and suppliers from all over the world. I belong to a big community that is making a difference in Africa!

I have never really been made to feel out of place in my career choice. On the contrary, I have been made to feel important for having developed an interest in science as a woman. The greatest challenge I have experienced though, was the struggle to have my skills and contribution recognized before I got a college degree. Some people have the wrong perception that anyone without a college degree is a failure–that is not true, I think my work spoke for me long before I got my degree!

There is need to encourage people to grow no matter what their background is. Some people simply lack opportunities or an enabling environment to help them excel. More people should stand out as role models and motivate those in the lower cadres who have the potential and are willing to grow in their career.

My greatest drive has been my ambition to progress and the encouragement I have received from other women who have made it in the world of science like the BecA-ILRI Hub technology manager, Josephine Birungi. I have also benefited from the support and flexibility of my supervisors and the encouragement from my peers.”

Lessons from an ‘ugly’ pig: BecA-ILRI Hub Director Appolinaire Djikeng discusses the role of livestock diversity in resilience for smallholder farmers in Africa

Smallholder livestock farming in sub Saharan Africa is associated with considerable risk and vulnerability. The challenging environmental conditions and limited resources available to support large livestock production present a major constraint to the development of this sector on the continent. Yet, Africa holds up to 70 percent of the livestock diversity in the world.

In addition to great diversity, African livestock includes species which possess attributes that give them resilience to diseases and other stresses that present a challenge to livestock production. During the fourth session of the International Fund for Agricultural Development (IFAD) AgTalks, the Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub director Appolinaire Djikeng gave his perspective on a fresh approach to livestock production which will help poor and vulnerable farming households in Africa climb up the livestock ladder out of poverty.

The N’dama cattle of West Africa are known to be trypanotolerant, and as such are able to populate tsetse fly infested regions of the continent where the tick-borne trypanosomiasis disease poses a significant challenge to livestock keeping. Still in West Africa, the prolific dwarf goat which produces up to four kids in one kidding has proved to be a great asset to smallholder farmers, enabling them to build large flocks for quick access to financial resources and nutrition. The Red Maasai sheep which are indigenous to East Africa possess resistance to endoparasites and thrive in very challenging arid environments, common in sub Saharan Africa.

In this nine minute video, Djikeng draws lessons from his childhood experience of the difference it made to own Cameroon’s unique ‘ugly’ pig during an Africa swine fever outbreak to address the issue of providing better opportunities for smallholder farming communities by utilizing the diversity of livestock as well as developing alternative livestock production systems in Africa.

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Read the full transcript here: http://ifad.org/agtalks/apollinaire.htm

Read related story here: Livestock, a lifeline for smallholder farmers

 

Defining the future of genomics in plant breeding

Appolinaire Djikeng, director, the BecA-ILRI Hub speaks on the role of genomics in plant breeding

The availability of genomics tools is transforming plant breeding by making it possible to identify and capitalize on their positive genetic traits. Genomics, or the study of genes and their interrelationships and functions, is giving plant breeders the means to accelerate the development of new higher yielding crop varieties that are capable of withstanding pests, diseases, or climate changes, and ultimately improve the global status of food and nutritional security.

In this three-minute video, Appolinaire Djikeng, director of the Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub in Nairobi, Kenya gives his views on the future of genomics in breeding and why research programs should invest more in the acquisition and application of genomics tools.

The BecA-ILRI Hub, a joint initiative of the African Union’s New Partnership for Africa’s Development (AU/NEPAD) and ILRI, is strengthening the capacity of African scientists to exploit advances in research by providing access to technologies previously unavailable in the region. The BecA-ILRI Hub genomics platform actively supports a wide range of research projects in molecular breeding as well as animal, crop and environmental health. Through a continued collaboration with researchers from African national agricultural research systems, the genomics platform is helping guide the design of strategies for increased agricultural productivity and crop and livestock disease management in Africa.

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Read more about the BecA-ILRI Hub Technologies and research related services